This species comes from South Africa, Mozambique, Zimbabwe and Malawi, but has become naturalised in many parts of the world.
Its most widespread use is ornamental, both in public and private gardens, appreciated both for its variegated habit and its showy inflorescences. Occasionally it is used to create hedges and boundaries.
In Portugal they make fishing nets with the fibres obtained from the bark of its leaves.

Aloe has important medicinal qualities, especially in the treatment of skin diseases, although many other properties are also attributed to it: digestive, purgative, analgesic, anti-inflammatory, bactericidal, cathartic, etc. It can be used both externally, topically, and internally, by ingesting its juices.
In recent times, the production and marketing of therapeutic products derived from aloe has become a major industry in the field of dermocosmetics and natural medicine.
In its regions of origin, it is used to provoke contractions to accelerate childbirth.

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